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← Celiac Disease

Gluten and immune injury & Digestive and extraintestinal symptoms

Lesson 1 · 5 min

Based on MedlinePlus en español — Celiac Disease. Original educational summary, read by a medical doctor and confirmed reliable, pending formal approval. Not medical advice.

Learning objectives

  • Explain gluten and immune injury.
  • Explain digestive and extraintestinal symptoms.

Gluten and immune injury

Celiac disease is a chronic immune and digestive disorder in which gluten exposure damages the small intestine. Gluten is found in wheat, barley, and rye and can occur in swallowed supplements or other products. Injury reduces absorption of nutrients. Genes and exposure contribute together, although the exact cause is not fully understood. The condition can therefore affect nutrition throughout the body rather than causing only temporary discomfort after a meal.

Digestive and extraintestinal symptoms

Bloating, pain, diarrhea, constipation, nausea, or greasy stools may occur. Children may fail to gain enough weight; adults may lose weight. Fatigue, mouth sores, bone or joint pain, and dermatitis herpetiformis are other possibilities. Some people have few symptoms. Untreated disease can contribute to iron-deficiency anemia, bone loss, nerve problems, or reproductive difficulties. A lack of obvious digestive symptoms does not exclude ongoing intestinal injury.

Key concepts

Gluten and immune injury
Celiac disease is a chronic immune and digestive disorder in which gluten exposure damages the small intestine.
Digestive and extraintestinal symptoms
Bloating, pain, diarrhea, constipation, nausea, or greasy stools may occur.
Distinguishing allergy and sensitivity
Wheat allergy and gluten sensitivity can resemble celiac disease but do not produce the same characteristic intestinal damage.
A lifelong gluten-free diet
A lifelong gluten-free diet controls disease and supports intestinal healing.

References